* How to get rid of Thumb.db file?
* How to stop Thumb.db file from being created automatically?
If you don't want Thumbs.db File to be created automatically?
1. My Computer
2. Tools Menu
3. Folder Option
4. View Tab
5. Check the Option: 'Dont Cache thumbnails'
And its done!
If still your computer generates Thumb.db files then your computer must be affected from virus / worms, etc.